Drug Name

Celebrex (Celecoxib)

Drug Uses

Celecoxib is tolerant of for the relief of pain, fever, bulge, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not abort the progression of either type of arthritis. It reduces no more than the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who require not had their colons removed. Celebrex also is approved for the replacement of acute pain and the exertion of menstrual cramps (predominant dysmenorrhea).

How to use

The lowest effectual dose should be habituated to for each patient. For the directorate of osteoarthritis, the dose all things considered is 100 mg twice regularly or 200 mg as a single dosage. For rheumatoid arthritis, the prescribe usually is 100 or 200 mg twice continuously. For acute pain or menstrual cramps, the quantity is 400 mg as a single dispense on the first day, followed by an additional 200 mg if needed, then 200mg twice ordinary as needed. For FAP, the recommended portion is 400 mg twice circadian.

Drug Class and Mechanism

Celecoxib is a nonsteroidal anti-frantic drug (NSAID) that is second-hand to treat arthritis, bother, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are superior contributors to the inflammation of arthritis that causes the trouble, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in decrease concentrations of prostaglandins. As a consequence, irritation and its accompanying pain, fever, nodule and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less swelling and ulceration of the stomach and intestine (at least with shorten-term treatment) and does not handicap with the clotting of blood. NSAIDs require been found to block the formation and reduce the volume of polyps in patients with the genetic virus, familial adenomatous polyposis (FAP). In FAP, patients reveal large numbers of polyps in their colons, and the polyps invariably evolve into malignant. The only prescription of FA

Missed Dose

Be the missed dose as in the end as you remember. If it is almost often for the next dose, jump the dose you missed and parody only the next regularly scheduled dose as directed. Do not memo a double dose of this medication unless your doctor directs otherwise.

Storage

Capsules should be stored at 25 degrees C (77 degrees F). It is okay for momentary periods in temperatures between 15-30 degrees C (59-86 degrees F).

Warnings/Precautions

There are no restrictions on nourishment, beverages, or activity while alluring celecoxib unless way directed by your doctor. Concomitant use of celecoxib with aspirin or other NSAIDs (e.g., ibuprofen, naproxen, etc.) may increase the development of stomach and intestinal ulcers. Fluconazole (Diflucan) increases the concentration of celecoxib in the heart by inhibiting the breakdown of celecoxib in the liver. For that reason, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are attractive fluconazole. Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%. Accordingly, lithium therapy should be closely monitored during and after cure with celecoxib. Persons, attractive the anticoagulant (blood thinner) warfarin (Coumadin), should have planned their blood tested when initiating or changing celecoxib treatment, uniquely in the first few days, for any changes in the effects of the anticoagulant. Persons, who gulp more than 3 intoxicating bevera

Possible Side Effects

Although countenance and intestinal ulcers enter someone's head with the use of celecoxib, their quantity is less than with other NSAIDs in succinct-term studies. Celecoxib does not poke one's nose in with the function of the blood platelets and, as a be produced end, does not reduce clotting and engender to increased bleeding like other NSAIDs. The most inferior adverse effects are difficulty, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia. Other side effects incorporate fainting, kidney default, heart failure, aggravation of hypertension, case pain, ringing in the ears, deafness, need and intestinal ulcers, bleeding, blurred idea, anxiety, photosensitivity, heaviness gain, water retention, flu-like symptoms, drowsiness and fondness. Allergic reactions can transpire with celecoxib. Individuals who keep developed allergic reactions (lots, itching, difficulty breathing) from sulfonamides (e.g., Bactrim), aspirin or other NSAIDs may ordeal an allergic reaction to celecoxib and should not regard as celecoxib.

More Information

Hint your doctor without hesitation if you develop abdominal pest, tenderness, or discomfort; nausea; bloody return food; bloody, black, or settle stools; unexplained bulk gain; swelling or D retention; fatigue or idleness; a skin rash; itching; yellowing of the fleece or eyes;\\"flu-like\\" symptoms; or uncommon bruising or bleeding. These symptoms could be antiquated signs of dangerous side effects. If you practice any of the following serious side effects, suppress taking celecoxib and solicit medical treatment or call on your doctor the moment that: an allergic reaction (fix breathing; closing of your throat; excrescence of your lips, whimsically, or face; or hives). Other, less not joking side effects may be more reasonable to occur. Continue to feel celecoxib and talk to your doctor if you undergo flatulence or diarrhea; dizziness; trouble; or insomnia. Side effects, other than those listed here, may also manifest itself. Talk to your doctor regarding any side effect that seems unique or that is especially bothersome.